RESUMEN
Resumen Antecedentes: los tratamientos con base en medicamentos contra la COVID-19 no han sido aprobados hasta la actualidad. La forma más efectiva de enfrentar este problema de salud pública es la prevención con una adecuada alimentación, medidas de higiene y protección. Los alimentos han sido históricamente utilizados por la población para mejorar su nutrición y complementar el tratamiento o prevención de enfermedades. Se conocen los diversos compuestos bioactivos de algunos alimentos, que en estudios experimentales demostraron su acción antiviral e inmunomoduladora. Objetivo: identificar los compuestos bioactivos o preparados de alimentos con potencial efecto inmunomodulador, inmunoestimulante y antiviral contra el coronavirus. Materiales y métodos: se realizó una búsqueda en Google Scholar, Scopus y en la Biblioteca Virtual de Salud en Bases de datos de Medicina Tradicional, Complementaria e Integrativa utilizando los términos food, immunomodulatory, immunostimulatory y antiviral en cuatro búsquedas sucesivas. Resultados: se obtuvieron 93 artículos y se identificó mayor evidencia sobre el efecto antiviral e inmunológico contra el coronavirus en nueve alimentos: Allium sativum, Cinnamomum zeylanicum, Citrus sinensis, Zingiber officinale, Vitis vinífera, Allium cepa, Curcuma longa, Punica granatum y Sambucus nigra. Los cuatro primeros mostraron actividad contra el SARS-CoV-2. Conclusiones: se evidenció el efecto inmunológico y antiviral contra el coronavirus de nueve alimentos; sin embargo, son estudios in silico e in vitro, por ello se requiere mayor investigación preclínica y clínica que lo confirmen.
Abstract Background: Up to date drug-based treatments for COVID-19 have not been approved. The most effective way to face this public health problem is prevention with adequate nutrition, hygiene, and protection measures. Food has historically been used by people to improve their nutrition and complement the treatment or prevention of diseases. The various bioactive compounds of some foods are known, which in experimental studies demonstrated their antiviral and immunomodulatory action. Objective: To identify bioactive compounds of foods or food preparations with potential immunomodulatory, immunostimulatory, and antiviral effects against coronavirus. Material and Methods: A search was carried out in Google Scholar, Scopus, and Virtual Health Library on Traditional Complementary and Integrative Medicine using the terms food, immunomodulatory, immunostimulatory, and antiviral in four successive searches. Results: 93 articles were obtained, and further evidence of antiviral and immunological effect against coronavirus was identified on nine foods: Allium sativum, Cinnamomum zeylanicum, Citrus sinensis, Zingiber officinale, Vitis vinifera, Allium cepa, Curcuma longa, Punica granatum, and Sambucus nigra. The first four of them showed activity against SARS-CoV-2. Conclusions: The immunological and antiviral effect against coronavirus of nine foods was evidenced; however, they are in silico and in vitro studies, therefore it is required further preclinical and clinical research to confirm this.
Asunto(s)
Antivirales , CoronavirusRESUMEN
O objetivo desse estudo foi avaliar a atividade antimicrobiana e antioxidante de polpa e casca do fruto de uxi. As amostras foram coletadas na cidade de Parintins - AM. Ao pesquisar a atividade antimicrobiana, as concentrações estudadas não apresentaram inibição do desenvolvimento microbiano, assim como para a atividade antioxidante, onde através dos extratos em DMSO, não houve inibição satisfatória do radical livre pelos métodos DPPH, ABTS e para compostos fenólicos totais. O estudo servirá como base para refinamentos direcionados ao estudo dessa temática.
The aim of this study was to evaluate the antimicrobial and antioxidant activity of uxi fruit pulp and rind. The samples were collected in the city of Parintins - AM. When investigating the antimicrobial activity, the studied concentrations did not show inhibition of microbial development, as well as the antioxidant activity, where through DMSO extracts, there was no satisfactory inhibition of free radical by DPPH, ABTS methods and for total phenolic compounds. The study will serve as a basis for refinements directed to the study of this theme.
Asunto(s)
Antiinfecciosos , Antioxidantes , FrutasRESUMEN
O objetivo desse estudo foi avaliar a atividade antimicrobiana e antioxidante de polpa e casca do fruto de uxi. As amostras foram coletadas na cidade de Parintins - AM. Ao pesquisar a atividade antimicrobiana, as concentrações estudadas não apresentaram inibição do desenvolvimento microbiano, assim como para a atividade antioxidante, onde através dos extratos em DMSO, não houve inibição satisfatória do radical livre pelos métodos DPPH, ABTS e para compostos fenólicos totais. O estudo servirá como base para refinamentos direcionados ao estudo dessa temática
The aim of this study was to evaluate the antimicrobial and antioxidant activity of uxi fruit pulp and rind. The samples were collected in the city of Parintins - AM. When investigating the antimicrobial activity, the studied concentrations did not show inhibition of microbial development, as well as the antioxidant activity, where through DMSO extracts, there was no satisfactory inhibition of free radical by DPPH, ABTS methods and for total phenolic compounds. The study will serve as a basis for refinements directed to the study of this theme
